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July 29, 2010

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Long-Term Ibuprofen Treatment After Brain Injury Worsens Cognitive Outcome

(Philadelphia, PA) - Researchers at the University of Pennsylvania School of Medicine found that chronic ibuprofen therapy given after brain injury worsens cognitive abilities. These findings - in a preliminary, animal-model study - have important implications for traumatic brain injury (TBI) patients who are often prescribed such nonsteroidal anti-inflammatory drugs (NSAIDS) as ibuprofen for chronic pain. The findings appear online this month in Experimental Neurology.

Because several studies in animals and humans have shown that long-term use of ibuprofen for inflammation improves outcome for Alzheimer's patients by reducing symptoms and delaying the onset of dementia, the researchers investigated whether ibuprofen improved long-term cognitive outcome in brain-injured animals.

Over four months, rats received ibuprofen in their food proportional to doses given to humans. In the two groups of injured rats (one fed ibuprofen and the other not), there was a significant overall deficit in the animals’ ability to find an underwater platform in a Morris water maze, a common test used to assess cognitive ability in animals. Read more at uphs.upenn.edu

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Did You Know?

Every 21 seconds, one person in the US sustains a Traumatic Brain Injury.

Traumatic Brain Injury (TBI) costs the country more than $48 billion a year, and between 2.5 and 6.5 million Americans alive today have had a TBI. Survivors of TBI are often left with significant cognitive, behavioral, and communicative disabilities, and some patients develop long-term medical complications, such as epilepsy.

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